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MTHFR 677 C>T and 1298 A>C polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer

Hereditary non-polyposis colorectal cancer (HNPCC) or Lynch syndrome is characterized by inactivating germline mutations in DNA mismatch repair genes resulting in an increased risk of developing an epithelial malignancy. There is considerable variability in disease expression observed in this syndro...

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Detalhes bibliográficos
Main Authors: Reeves, Stuart G, Meldrum, Cliff, Groombridge, Claire, Spigelman, Allan D, Suchy, Janina, Kurzawski, Grzegorz, Lubinski, Jan, McElduff, Patrick, Scott, Rodney J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2986255/
https://ncbi.nlm.nih.gov/pubmed/19156174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2008.239
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