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Evolution of a bifunctional enzyme: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

The bifunctional rat liver enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (ATP:D-fructose-6-phosphate 2-phosphotransferase/D-fructose-2,6-bisphosphate 2-phosphohydrolase, EC 2.7.1.105/EC 3.1.3.46) is constructed of two independent catalytic domains. We present evidence that the kinase a...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Bazan, J F, Fletterick, R J, Pilkis, S J
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1989
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298557/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2557623/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.24.9642
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