Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease.

Rat fibroblasts were infected with a retroviral vector containing the cDNA for rat tyrosine hydroxylase [TH; tyrosine 3-monooxygenase; L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2]. A TH-positive clone was identified by biochemical assay and immunohistochemic...

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Autori principali: Wolff, J A, Fisher, L J, Xu, L, Jinnah, H A, Langlais, P J, Iuvone, P M, O'Malley, K L, Rosenberg, M B, Shimohama, S, Friedmann, T
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1989
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC298422/
https://ncbi.nlm.nih.gov/pubmed/2573072
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