IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants

IL-27, consisting of the subunits IL-27p28 and Epstein–Barr virus-induced gene 3 (EBI3), is a heterodimeric cytokine belonging to the IL-6/IL-12 family of cytokines. IL-27p28 is a four-helical cytokine requiring association with the soluble receptor EBI3 to be efficiently secreted and functionally a...

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Detalles Bibliográficos
Main Authors: Rousseau, Francois, Basset, Laetitia, Froger, Josy, Dinguirard, Nathalie, Chevalier, Sylvie, Gascan, Hugues
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984150/
https://ncbi.nlm.nih.gov/pubmed/20974977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005793107
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