Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase.

A plasmid was constructed in which a single guanine residue was replaced with either O6-methylguanine or O6-ethylguanine, two of the DNA adducts formed by carcinogenic alkylating agents. The vectors were introduced in parallel into a pair of Chinese hamster ovary cells, in which one member of the pa...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Ellison, K S, Dogliotti, E, Connors, T D, Basu, A K, Essigmann, J M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298339/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2813414/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.22.8620
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