Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics and Effect on the Insulin-like Growth Factor Axis

Resveratrol, a naturally occurring polyphenol, has cancer chemopreventive properties in preclinical models. It has been shown to downregulate levels of insulin-like growth factor-1 (IGF-1) in rodents. The purpose of the study was to assess its safety, pharmacokinetics and effects on circulating leve...

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Main Authors: Brown, Victoria A, Patel, Ketan R, Viskaduraki, Maria, Crowell, James A, Perloff, Marjorie, Booth, Tristan D, Vasilinin, Grygoriy, Sen, Ananda, Schinas, Anna Maria, Piccirilli, Gianfranca, Brown, Karen, Steward, William P, Gescher, Andreas J, Brenner, Dean E
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982884/
https://ncbi.nlm.nih.gov/pubmed/20935227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2364
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