Expression of TL, H-2, and chimeric H-2/TL genes in transgenic mice: abnormal thymic differentiation and T-cell lymphomas in a TL transgenic strain.

To investigate the genetic regulation of TL expression, 12 transgenic mouse strains on a C3H (TL-nonexpressing) background have been derived: two Tg.Tlaa-3 strains with Tlaa-3 isolated from A-strain TL+ thymocytes, four Tg.T3b strains with T3b from a TL+ leukemia arising in a C57BL/6 (TL-) mouse, th...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Hamasima, N, Takahashi, T, Taguchi, O, Nishizuka, Y, Stockert, E, Old, L J, Obata, Y
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 1989
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298200/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2813374/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.20.7995
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