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Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase
Sphingolipid metabolism is driven by inflammatory cytokines. These cascade of events include the activation of sphingosine kinase (SK), and subsequent production of the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P). Overall, S1P is one of the crucial components in inflammation, m...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2981458/ https://ncbi.nlm.nih.gov/pubmed/20688834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgq158 |
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