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Trapping Moving Targets with Small Molecules
Structure-based drug design traditionally uses static protein models as inspirations for focusing on “active” site targets. Allosteric regulation of biological macromolecules, however, is affected by both conformational and dynamic properties of the protein or protein complex, and can potentially le...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2981433/ https://ncbi.nlm.nih.gov/pubmed/19359579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1169378 |
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