Surface Expression of MPT64 as a Fusion with the PE Domain of PE_PGRS33 Enhances Mycobacterium bovis BCG Protective Activity against Mycobacterium tuberculosis in Mice

To improve the current vaccine against tuberculosis, a recombinant strain of Mycobacterium bovis bacillus Calmette-Guérin (rBCG) expressing a Mycobacterium tuberculosis vaccine candidate antigen (MPT64) in strong association with the mycobacterial cell wall was developed. To deliver the candidate an...

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Bibliographic Details
Main Authors: Sali, Michela, Di Sante, Gabriele, Cascioferro, Alessandro, Zumbo, Antonella, Nicolò, Chiara, Donà, Valentina, Rocca, Stefano, Procoli, Annabella, Morandi, Matteo, Ria, Francesco, Palù, Giorgio, Fadda, Giovanni, Manganelli, Riccardo, Delogu, Giovanni
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981302/
https://ncbi.nlm.nih.gov/pubmed/20921146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00267-10
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