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A(1),(3)-strain enabled retention of chirality during bis-cyclization of β-ketoamides: total synthesis of (−)-salinosporamide A and (−)-homosalinosporamide A
A concise, enantioselective synthesis of the Phase I anticancer agent, (−)-salinosporamide A, is described. The brevity of the described strategy stems from a key bis-cyclization of a β-keto tertiary amide, accomplished on gram scale, which retains optical purity enabled by A(1),(3)-strain rendering...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2981177/ https://ncbi.nlm.nih.gov/pubmed/20498903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0cc00607f |
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