Differences in the negative allosteric modulation of gamma-aminobutyric acid receptors elicited by 4'-chlorodiazepam and by a beta-carboline-3-carboxylate ester: a study with natural and reconstituted receptors.

Cl- currents elicited by gamma-aminobutyric acid (GABA) application were recorded with the whole-cell tight-seal technique from voltage-clamped cortical neurons of neonatal rats in primary culture. The peripheral benzodiazepine recognition site ligand 4'-chlorodiazepam [Ro 5-4864; 7-chloro-1,3-...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Puia, G, Santi, M R, Vicini, S, Pritchett, D B, Seeburg, P H, Costa, E
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1989
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298040/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2476816/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.18.7275
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