Phosphorothioate and cordycepin analogues of 2',5'-oligoadenylate: inhibition of human immunodeficiency virus type 1 reverse transcriptase and infection in vitro.

Natural antiviral activity can be mediated by the interferon-induced synthesis of 2',5'-oligoadenylates (2-5As) and subsequent RNase L activation by these molecules. Analogues of 2-5A that are biologically active and metabolically stable were synthesized and analyzed for antiviral activity...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Montefiori, D C, Sobol, R W, Li, S W, Reichenbach, N L, Suhadolnik, R J, Charubala, R, Pfleiderer, W, Modliszewski, A, Robinson, W E, Mitchell, W M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298022/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2476814/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.18.7191
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