The detrimental effects of interferon-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction.

Systemic lupus erythematosus (SLE) is characterized by increased vascular risk due to premature atherosclerosis independent of traditional risk factors. We previously proposed that Interferon-α (IFN-α) plays a crucial role in premature vascular damage in SLE. IFN-α alters the balance between endothe...

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Библиографические подробности
Главные авторы: Thacker, Seth G., Berthier, Celine C., Mattinzoli, Deborah, Rastaldi, Maria Pia, Kretzler, Matthias, Kaplan, Mariana J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978924/
https://ncbi.nlm.nih.gov/pubmed/20805419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001782
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