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THE ANTILYMPHOCYTIC ACTIVITY OF BREQUINAR SODIUM AND ITS POTENTIATION BY CYTIDINE: Effects On Lymphocyte Proliferation and Cytokine Production
Based on its capacity to inhibit de novo pyrimidine biosynthesis by blocking dihydroorotate dehydrogenase activity, the antitumor agent brequinar sodium (BQR) has emerged as a new immunosuppressive agent. Since BQR is known to prevent the synthesis of nucleotides during cell proliferation, we hypoth...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2978649/ https://ncbi.nlm.nih.gov/pubmed/8356593 |
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