Histidine Residues in the Na(+)-coupled Ascorbic Acid Transporter-2 (SVCT2) Are Central Regulators of SVCT2 Function, Modulating pH Sensitivity, Transporter Kinetics, Na(+) Cooperativity, Conformational Stability, and Subcellular Localization

Na(+)-coupled ascorbic acid transporter-2 (SVCT2) activity is impaired at acid pH, but little is known about the molecular determinants that define the transporter pH sensitivity. SVCT2 contains six histidine residues in its primary sequence, three of which are exofacial in the transporter secondary...

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Main Authors: Ormazabal, Valeska, Zuñiga, Felipe A., Escobar, Elizabeth, Aylwin, Carlos, Salas-Burgos, Alexis, Godoy, Alejandro, Reyes, Alejandro M., Vera, Juan Carlos, Rivas, Coralia I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978576/
https://ncbi.nlm.nih.gov/pubmed/20843809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.155630
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