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Design, Synthesis and Biological Evaluation of A Novel Class of Anticancer Agents: Anthracenylisoxazole Lexitropsin Conjugates

The synthesis and in vitro anti-tumor 60 cell lines screen of a novel series of anthracenyl isoxazole amides (AIMs) (22–33) is described. The molecules consist of an isoxazole that pre-organizes a planar aromatic moiety and a simple amide and/or lexitropsin-oligopeptide. The new conjugate molecules...

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Bibliografiske detaljer
Main Authors: Han, Xiaochun, Li, Chun, Mosher, Michael D., Rider, Kevin C., Zhou, Peiwen, Crawford, Ronald L., Fusco, William, Paszczynski, Andrzej, Natale, Nicholas R.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978248/
https://ncbi.nlm.nih.gov/pubmed/19167892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.12.056
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