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Process Optimization, Characterization and Pharmacokinetic Evaluation in Rats of Ursodeoxycholic Acid–Phospholipid Complex

The purpose of this research was to study whether the bioavailability of ursodeoxycholic acid could be improved by administering ursodeoxycholic acid–phospholipid complex (UDCA–PLC) orally to rats. A central composite design approach was used for process optimization in order to obtain the acceptabl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yue, Peng-Fei, Zhang, Wen-Jin, Yuan, Hai-Long, Yang, Ming, Zhu, Wei-Feng, Cai, Pei-Lie, Xiao, Xiao-He
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976878/
https://ncbi.nlm.nih.gov/pubmed/18446498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-008-9040-1
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