Synthesis and characterization of a series of diarylguanidines that are noncompetitive N-methyl-D-aspartate receptor antagonists with neuroprotective properties.

Four diarylguanidine derivatives were synthesized. These compounds were found to displace, at submicromolar concentrations, 3H-labeled 1-[1-(2-thienyl)cyclohexyl]piperidine and (+)-[3H]MK-801 from phencyclidine receptors in brain membrane preparations. In electrophysiological experiments the diarylg...

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Main Authors: Keana, J F, McBurney, R N, Scherz, M W, Fischer, J B, Hamilton, P N, Smith, S M, Server, A C, Finkbeiner, S, Stevens, C F, Jahr, C
Formato: Artigo
Idioma:Inglês
Publicado: 1989
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC297678/
https://ncbi.nlm.nih.gov/pubmed/2546162
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