A Double Mutation in Glycoprotein gB Compensates for Ineffective gD-Dependent Initiation of Herpes Simplex Virus Type 1 Infection

Herpes simplex virus (HSV) entry into cells is triggered by the binding of envelope glycoprotein D (gD) to a specific receptor, such as nectin-1 or herpesvirus entry mediator (HVEM), resulting in activation of the fusion effectors gB and gH and virus penetration. Here we report the identification of...

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Autors principals: Uchida, Hiroaki, Chan, Janet, Goins, William F., Grandi, Paola, Kumagai, Izumi, Cohen, Justus B., Glorioso, Joseph C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Virus-Cell Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976401/
https://ncbi.nlm.nih.gov/pubmed/20861246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01633-10
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