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Cooperative Action of Multiple cis-Acting Elements Is Required for N-myc Expression in Branchial Arches: Specific Contribution of GATA3

The precise expression of the N-myc proto-oncogene is essential for normal mammalian development, whereas altered N-myc gene regulation is known to be a determinant factor in tumor formation. Using transgenic mouse embryos, we show that N-myc sequences from kb −8.7 to kb +7.2 are sufficient to repro...

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Autors principals: Potvin, Éric, Beuret, Laurent, Cadrin-Girard, Jean-François, Carter, Marcelle, Roy, Sophie, Tremblay, Michel, Charron, Jean
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976382/
https://ncbi.nlm.nih.gov/pubmed/20855530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00353-09
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