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Functional inhibition of endogenously produced urokinase decreases cell proliferation in a human melanoma cell line.

Binding of urokinase-type plasminogen activator (u-PA) to its receptor has been shown not only to focus proteolytic activity to the cell surface but also to exert a mitogenic effect on the human epidermal tumor cell line CCL 20.2. This report shows that u-PA is an autocrine mitogen in the human mela...

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Bibliografske podrobnosti
Main Authors: Kirchheimer, J C, Wojta, J, Christ, G, Binder, B R
Format: Artigo
Jezik:Inglês
Izdano: 1989
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC297635/
https://ncbi.nlm.nih.gov/pubmed/2501786
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