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A Single, Engineered Protein Therapeutic Agent Neutralizes Exotoxins from Both Staphylococcus aureus and Streptococcus pyogenes

Staphylococcus aureus and Streptococcus pyogenes secrete exotoxins that act as superantigens, proteins that cause hyperimmune reactions by binding the variable domain of the T-cell receptor beta chain (Vβ), leading to stimulation of a large fraction of the T-cell repertoire. To develop potential neu...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Ningyan, Mattis, Daiva M., Sundberg, Eric J., Schlievert, Patrick M., Kranz, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976085/
https://ncbi.nlm.nih.gov/pubmed/20861327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00277-10
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