Inhibition of radiation-induced neoplastic transformation by beta-lapachone.

Beta-lapachone is a potent inhibitor of DNA repair in mammalian cells and activates topoisomerase I. We show that beta-lapachone can prevent the oncogenic transformation of CHEF/18A cells by ionizing radiation. Potentially lethal DNA damage repair (PLDR) occurs while x-irradiated cells are held in m...

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Bibliografiska uppgifter
Huvudupphovsmän: Boothman, D A, Pardee, A B
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1989
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC297536/
https://ncbi.nlm.nih.gov/pubmed/2740334
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