Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virus

The M2 protein of influenza A virus performs the crucial function of transporting protons to the interior of virions enclosed in the endosome. Adamantane drugs, amantadine (AMN) and rimantidine (RMN), block the proton conduction in some strains, and have been used for the treatment and prophylaxis o...

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Hlavní autoři: Khurana, Ekta, DeVane, Russell H., Peraro, Matteo Dal, Klein, Michael L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975046/
https://ncbi.nlm.nih.gov/pubmed/20385097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2010.03.025
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