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Cadmium Impairs Albumin Reabsorption by Down-regulating Megalin and ClC5 Channels in Renal Proximal Tubule Cells

BACKGROUND: Cadmium (Cd) is a potent nephrotoxicant that impairs the reabsorptive and secretory functions of the renal proximal tubule, leading to albuminuria. OBJECTIVES: To gain insights into the mechanisms of Cd-induced albuminuria, we investigated effects of Cd on the expression of megalin and c...

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Sonraí Bibleagrafaíochta
Main Authors: Gena, Patrizia, Calamita, Giuseppe, Guggino, William B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Institute of Environmental Health Sciences 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974692/
https://ncbi.nlm.nih.gov/pubmed/20576581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.0901874
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