Down-Regulation of Serum/Glucocorticoid Regulated Kinase 1 in Colorectal Tumours Is Largely Independent of Promoter Hypermethylation

BACKGROUND: We have previously shown that serum/glucocorticoid regulated kinase 1 (SGK1) is down-regulated in colorectal cancers (CRC) with respect to normal tissue. As hyper-methylation of promoter regions is a well-known mechanism of gene silencing in cancer, we tested whether the SGK1 promoter re...

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Autori principali: Lessi, Francesca, Beggs, Andrew, de Palo, Mariagrazia, Anti, Marcello, Macarone Palmieri, Raffaele, Francesconi, Simona, Gomes, Vito, Bevilacqua, Generoso, Tomlinson, Ian, Segditsas, Stefania
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974649/
https://ncbi.nlm.nih.gov/pubmed/21079778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013840
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