Pivotal Advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms

TLRs and complement are critical to the host response in sepsis, trauma, and ischemia/reperfusion. We hypothesize that TLR stimulation leads to synthesis and release of complement components by macrophages, an important source of extrahepatic complement. RAW264.7 macrophages or peritoneal macrophage...

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Hlavní autoři: Kaczorowski, David J., Afrazi, Amin, Scott, Melanie J., Kwak, Joon H., Gill, Roop, Edmonds, Rebecca D., Liu, Yujian, Fan, Jie, Billiar, Timothy R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Leukocyte Biology 2010
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Pivotal Advance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974428/
https://ncbi.nlm.nih.gov/pubmed/20413727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0809588
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