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Inhibition of Ca(2+)-activated Cl(−) channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea

TMEM16A was found recently to be a calcium-activated Cl(−) channel (CaCC). CaCCs perform important functions in cell physiology, including regulation of epithelial secretion, cardiac and neuronal excitability, and smooth muscle contraction. CaCC modulators are of potential utility for treatment of h...

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Détails bibliographiques
Auteurs principaux: Namkung, Wan, Thiagarajah, Jay R., Phuan, Puay-Wah, Verkman, A. S.
Format: Artigo
Langue:Inglês
Publié: Federation of American Societies for Experimental Biology 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974422/
https://ncbi.nlm.nih.gov/pubmed/20581223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-160648
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