Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants

The OGG1 gene encodes a highly conserved DNA glycosylase that repairs oxidized guanines in DNA. We have investigated the in vivo function of the Ogg1 protein in yeast mitochondria. We demonstrate that inactivation of ogg1 leads to at least a 2-fold increase in production of spontaneous mitochondrial...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Singh, Keshav K., Sigala, Barbara, Sikder, Hashmat A., Schwimmer, Christine
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29743/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11239005/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.6.1381
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