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Tablet Splitting of a Narrow Therapeutic Index Drug: A Case with Levothyroxine Sodium
Levothyroxine is a narrow therapeutic index, and to avoid adverse effect associated with under or excessive dosage, the dose response is carefully titrated. The tablets are marketed with a score providing an option to split. However, there are no systematic studies evaluating the effect of splitting...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2974142/ https://ncbi.nlm.nih.gov/pubmed/20740332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9515-8 |
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