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Ultrasound-Enhanced Drug Transport and Distribution in the Brain

Drug delivery in the brain is limited by slow drug diffusion in the brain tissue. This study tested the hypothesis that ultrasound can safely enhance the permeation of drugs in the brain. In vitro exposure to ultrasound at various frequencies (85 kHz, 174 kHz, and 1 MHz) enhanced the permeation of t...

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Autors principals: Liu, Ying, Paliwal, Sumit, Bankiewicz, Krystof S., Bringas, John R., Heart, Gill, Mitragotri, Samir, Prausnitz, Mark R.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974134/
https://ncbi.nlm.nih.gov/pubmed/20532711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9458-0
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