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Optimization of PEGylation Conditions for BSA Nanoparticles Using Response Surface Methodology
Chemical coupling of polyethylene glycol (PEG) to proteins or particles (PEGylation), prolongs their circulation half-life by greater than 50-fold, reduces their immunogenicity, and also promotes their accumulation in tumors due to enhanced permeability and retention effect. Herein, phase separation...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Springer US
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2974113/ https://ncbi.nlm.nih.gov/pubmed/20680708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9487-8 |
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