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Optimization of PEGylation Conditions for BSA Nanoparticles Using Response Surface Methodology

Chemical coupling of polyethylene glycol (PEG) to proteins or particles (PEGylation), prolongs their circulation half-life by greater than 50-fold, reduces their immunogenicity, and also promotes their accumulation in tumors due to enhanced permeability and retention effect. Herein, phase separation...

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Autors principals: Kouchakzadeh, Hasan, Shojaosadati, Seyed Abbas, Maghsoudi, Amir, Vasheghani Farahani, Ebrahim
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974113/
https://ncbi.nlm.nih.gov/pubmed/20680708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9487-8
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