Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex

Experience-dependent cortical plasticity has been studied by using loss-of-function methods. Here, we take the complementary approach of using a genetic gain-of-function that enhances plasticity. We show that a constitutively active form of H-ras (H-ras(G12V)), expressed presynaptically at excitator...

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Bibliographic Details
Main Authors: Kaneko, Megumi, Cheetham, Claire E., Lee, Yong-Seok, Silva, Alcino J., Stryker, Michael P., Fox, Kevin
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973899/
https://ncbi.nlm.nih.gov/pubmed/20937865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013866107
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