Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a progressive and fatal genetic disorder of muscle degeneration. Patients with DMD lack expression of the protein dystrophin as a result of mutations in the X-linked dystrophin gene. The loss of dystrophin leads to severe skeletal muscle pathologies as well as ca...

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Autori principali: Adamo, Candace M., Dai, Dao-Fu, Percival, Justin M., Minami, Elina, Willis, Monte S., Patrucco, Enrico, Froehner, Stanley C., Beavo, Joseph A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973894/
https://ncbi.nlm.nih.gov/pubmed/20956307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013077107
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