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3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1

Studies of long-lived Caenorhabditis elegans mutants have identified several genes that function to limit lifespan, i.e., loss-of-function mutations in these genes promote longevity. By contrast, little is known about genes that normally act to delay aging and that when mutated cause premature aging...

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Detalhes bibliográficos
Main Authors: Berdichevsky, Alina, Nedelcu, Simona, Boulias, Konstantinos, Bishop, Nicholas A., Guarente, Leonard, Horvitz, H. Robert
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973869/
https://ncbi.nlm.nih.gov/pubmed/20956318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013854107
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