Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules

Most antigenic peptides presented by MHC class I molecules result from the degradation of intracellular proteins by the proteasome. In lymphoid tissues and cells exposed to IFNγ, the standard proteasome is replaced by the immunoproteasome, in which all of the standard catalytic subunits β1, β2, and...

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Hlavní autoři: Guillaume, Benoît, Chapiro, Jacques, Stroobant, Vincent, Colau, Didier, Van Holle, Benoît, Parvizi, Grégory, Bousquet-Dubouch, Marie-Pierre, Théate, Ivan, Parmentier, Nicolas, Van den Eynde, Benoît J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972972/
https://ncbi.nlm.nih.gov/pubmed/20937868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009778107
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