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Nuclear Receptor COUP-TFII Controls Pancreatic Islet Tumor Angiogenesis by Regulating VEGF/VEGFR-2 Signaling

The significance of angiogenesis in cancer biology and therapy is well established. In this study, we utilized the prototypical RIP-Tag model of multistage pancreatic islet tumorigenesis to show that the nuclear receptor COUP-TFII is essential to regulate the balance between pro- and anti-angiogenic...

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Detalhes bibliográficos
Main Authors: Qin, Jun, Chen, Xinpu, Yu-Lee, Li-yuan, Tsai, Ming-Jer, Tsai, Sophia Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970665/
https://ncbi.nlm.nih.gov/pubmed/20978203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0551
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