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Genetic Polymorphisms in the Thioredoxin 2 (TXN2) Gene and Risk for Spina Bifida

TXN2 encodes human thioredoxin 2, a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Txn2 knockout mice fail to complete neural tube closure by E10.5 and die in utero. We hypothesized that genetic variation in human TXN2 gene may alter the fu...

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Detalhes bibliográficos
Main Authors: Wen, Shu, Lu, Wei, Zhu, Huiping, Yang, Wei, Shaw, Gary M., Lammer, Edward J., Islam, Ana, Finnell, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970524/
https://ncbi.nlm.nih.gov/pubmed/19165900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.a.32589
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