Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.

A membrane-bound cytochrome b, a heterodimer formed by a 91-kD glycoprotein (heavy chain) and a 22-kD polypeptide (light chain), is an essential component of the phagocyte NADPH-oxidase responsible for superoxide generation. Cytochrome b is absent in two subgroups of chronic granulomatous disease (C...

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Pubblicato in:	J Clin Invest
Autori principali:	Dinauer, M C, Pierce, E A, Bruns, G A, Curnutte, J T, Orkin, S H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296926/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2243141/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114898
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