Blockade of Osteopontin Inhibits Glomerular Fibrosis in a Model of Anti-Glomerular Basement Membrane Glomerulonephritis

BACKGROUND: In our rat model for anti-GBM GN, severe fibrosis follows glomerular inflammation. A potential role of extracellular matrix protein osteopontin (OPN) in glomerular fibrosis was investigated. METHODS: Neutralizing OPN antiserum or control normal serum was injected into the experimental ra...

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Bibliographic Details
Main Authors: Zhou, Cindy, Wu, Jean, Torres, Lisa, Hicks, John M., Bartkowiak, Todd, Parker, Kiana, Lou, Ya-Huan
Format: Artigo
Language:Inglês
Published: S. Karger AG 2010
Subjects:
Original Report: Laboratory Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2969149/
https://ncbi.nlm.nih.gov/pubmed/20720406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000319490
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