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An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

A polymorphism consisting of the presence or absence of a 250-bp DNA fragment was detected within the angiotensin I-converting enzyme gene (ACE) using the endothelial ACE cDNA probe. This polymorphism was used as a marker genotype in a study involving 80 healthy subjects, whose serum ACE levels were...

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Udgivet i:J Clin Invest
Principais autores: Rigat, B, Hubert, C, Alhenc-Gelas, F, Cambien, F, Corvol, P, Soubrier, F
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296868/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1976655/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114844
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