Interferon-gamma overcomes glucocorticoid suppression of cachectin/tumor necrosis factor biosynthesis by murine macrophages.

Glucocorticoids almost completely inhibit the synthesis by isolated macrophages of cachectin/tumor necrosis factor (TNF), a cytokine implicated as a major endogenous mediator of septic shock. Despite this in vitro effectiveness, the clinical use of glucocorticoids has failed to demonstrate any clear...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Luedke, C E, Cerami, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296853/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2120285/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114829
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