Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

Long intergenic noncoding RNAs (lincRNAs) regulate chromatin states and epigenetic inheritance. Here we show that the lincRNA HOTAIR serves as a scaffold for at least two distinct histone modification complexes. A 5′ domain of HOTAIR binds Polycomb Repressive Complex 2 (PRC2) while a 3′ domain of HO...

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Bibliografiske detaljer
Main Authors: Tsai, Miao-Chih, Manor, Ohad, Wan, Yue, Mosammaparast, Nima, Wang, Jordon K., Lan, Fei, Shi, Yang, Segal, Eran, Chang, Howard Y.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967777/
https://ncbi.nlm.nih.gov/pubmed/20616235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1192002
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