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Detection of Phenolic Metabolites of Styrene in Mouse Liver and Lung Microsomal Incubations
Metabolic activation is considered to be a critical step for styrene-induced pulmonary toxicity. Styrene-7,8-oxide is a primary oxidative metabolite generated by vinyl epoxidation of styrene. In addition, urinary 4-vinylphenol (4-VP), a phenolic metabolite formed by aromatic hydroxylation, has been...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Pharmacology and Experimental
Therapeutics
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2967389/ https://ncbi.nlm.nih.gov/pubmed/20724499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.033522 |
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