Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L

The pore-forming protein perforin is synthesized as an inactive precursor in natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), and becomes active when a short C-terminal peptide is cleaved within acidic lysosome-like cytotoxic granules. Although it was shown more than a decade ago that t...

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Bibliografiske detaljer
Main Authors: Konjar, Špela, Sutton, Vivien R, Hoves, Sabine, Repnik, Urška, Yagita, Hideo, Reinheckel, Thomas, Peters, Christoph, Turk, Vito, Turk, Boris, Trapani, Joseph A, Kopitar-Jerala, Nataša
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2010
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967271/
https://ncbi.nlm.nih.gov/pubmed/20497254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2010.03299.x
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