Mechanism of genotoxicity induced by targeted cytoplasmic irradiation

BACKGROUND: Direct damage to DNA is generally accepted as the main initiator of mutation and cancer induced by environmental carcinogens or ionising radiation. However, there is accumulating evidence suggesting that extracellular/extranuclear targets may also have a key role in mediating the genotox...

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Bibliographic Details
Main Authors: Hong, M, Xu, A, Zhou, H, Wu, L, Randers-Pehrson, G, Santella, R M, Yu, Z, Hei, T K
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
Subjects:
Genetics and Genomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967061/
https://ncbi.nlm.nih.gov/pubmed/20842121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605888
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