Roles of Tetrahydrobiopterin in Promoting Tumor Angiogenesis

Nitric oxide (NO), which is derived from endothelial NO synthase (eNOS), provides crucial signals for angiogenesis in the tumor microenvironment. Tetrahydrobiopterin (BH4) is an absolute requirement for eNOS activity. In this study, we investigated whether this activation is both maintained by a wil...

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Detalhes bibliográficos
Main Authors: Chen, Liye, Zeng, Xin, Wang, Jihui, Briggs, Simon S., O'Neill, Eric, Li, Jiliang, Leek, Russell, Kerr, David J., Harris, Adrian L., Cai, Shijie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966821/
https://ncbi.nlm.nih.gov/pubmed/20847284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100025
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