Activity and safety of NGR-hTNF, a selective vascular-targeting agent, in previously treated patients with advanced hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) is a highly vascularised and poor-prognosis tumour. NGR-hTNF is a vascular-targeting agent consisting of human tumour necrosis factor-alpha fused to the tumour-homing peptide NGR, which is able to selectively bind an aminopeptidase N overexpressed on tumour...

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Hlavní autoři: Santoro, A, Pressiani, T, Citterio, G, Rossoni, G, Donadoni, G, Pozzi, F, Rimassa, L, Personeni, N, Bozzarelli, S, Colombi, S, De Braud, F G, Caligaris-Cappio, F, Lambiase, A, Bordignon, C
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966632/
https://ncbi.nlm.nih.gov/pubmed/20717115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605858
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