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Chemopreventive efficacy of rapamycin on Peutz–Jeghers syndrome in a mouse model
Germline mutations in LKB1 cause Peutz–Jeghers syndrome (PJS), an autosomal dominant disorder with a predisposition to gastrointestinal polyposis and cancer. Hyperactivation of mTOR-signaling has been associated with PJS. We previously reported that rapamycin treatment of LKB1(+/−) mice after the on...
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| Main Authors: | , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2009
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2966387/ https://ncbi.nlm.nih.gov/pubmed/19147279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2008.11.036 |
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